The University of Rochester has developed an implantable biosensors that uses live cells to detect biochemical changes using photonics technology:
A study revealed at this year’s Heart Rhythm Society Meeting presented the first in-human results of a leadless implantable pacemaker. The device is about the size of a AAA battery and is implanted in the right ventricle. A limitation of current pacemakers is the reliance on implantable leads that can fracture or become infected. This device is the first step toward developing leadless pacing technologies. It remains to be seen how clinically useful this device will be but is expected to be available in Europe later this year.
- Nanostim’s Mini Wireless Pacemaker Shows Promise in Study (bloomberg.com)
- Wireless Pacemaker Shows Promise in Early Study (news.health.com)
- Wireless Pacemaker Shows Promise in Early Study (webmd.com)
Pharmaco-Kinesis Corporation has developed an implantable pump for localized cancer-fighting drug delivery. This first-generation Nano-Impedance Biosensor (NIB) detects vascular endothelial growth factor (VEGF-165) which is a biomarker correlating to the presence of a cancerous tumor in the body. The NIB is about the size of an aspirin and can detect VEGF at levels as low as 1 to 10 protein molecules in the billions of molecules present in 1 mL of body fluid. Products using NIB technology could ultimately become available over-the-counter to enable patients to measure biomarkers for cancer and other chronic illnesses. One can envision implantable sensors to track brain natriuretic peptide or troponin to enable instant therapy delivery for cardiovascular patients.
Image taken from http://www.wired.co.uk/news/archive/2013-03/20/implantable-chip-doctor.
A multidisciplinary Swiss team has developed a tiny implantable chip that can test blood and wirelessly transmit the information to doctors.
Giovanni de Micheli and Sandro Carrara of École Polytechnique Fédérale de Lausanne (EPFL) invented the 14mm-long device. The device is a chip fitted with five sensors and a radio transmitter and is powered via inductive coupling with a battery patch worn outside the body delivering a tenth of a watt in energy. The chip is Bluetooth-equipped to transfer the data picked up by the chip’s radio signals.
The researchers’ goals are to use the chip to monitor five different molecules which may represent five different disease states. This proof-of-concept device has exciting implications for the field of personalized medicine; each person’s biological signals can be recorded and therapy tailored for each individual.
Advances in modern medicine are increasingly relying on electronic devices implanted inside the patient’s body. Nanotechnology allows us to create materials and coatings to construct these devices that are fully biocompatible.
Researchers from the University of Illinois at Urbana-Champaign recently developed silk-silicon implantable microcircuits that begin to dissolve two weeks after implantation. These particular implantable devices were designed to produce heat to fight infection after surgery. When the device were implanted in mice, they found that infection was reduced and only faint traces of the device remained after three weeks. These transient implantable devices may have far-ranging applications not only in medicine but in reducing electronic waste.
Nokia has introduced a smart phone that can charge itself wirelessly. (http://www.nokia.com/global/products/lumia/) It is safe to assume that Nokia uses induction based technology to charge the phone. The phone (equipped with a special receiver) is placed on a mat that generates an electromagnetic field. The phone’s special receiver uses this electromagnetic field to charge the phone’s battery. This technology can only power one device at a time and may generate heat during the charging process.
Recently, IDT and Intel partnered to announce the development of an integrated transmitter and receiver chipset for Intel’s wireless charging technology based on resonance technology. (IDT and Intel Partnership) Magnetic resonance uses electrical components (a coil and a capacitor) to create magnetic resonance. This resonance can then transmit electricity to the receiver (device to be charged) from the transmitter (charging base). Magnetic resonance can power multiple devices at a time and may not generate excessive heat. A nice summary of this technology is available at Fujitsu Summary of Wireless Charging.
These technologies can be disruptive forces in the medical device industry that rely on battery depletion and replacement for subsequent sales (e.g., pacemakers, defibrillator, and noncardiac pulse generators). The device company that incorporates wireless charging into their devices may minimize replacement procedures for patients (and limiting procedural risk) while at the same time stabilizing their market position. Future device upgrades may be software upgrades and licensing that can be performed wirelessly without need for invasive procedure.